Adipocyte cholesterol balance in obesity
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Submitted by Soazig Le Lay on Tue, 01/27/2015 10:41 Titre Adipocyte cholesterol balance in obesity. Type de publication Article de revue Auteur Le Lay, Soazig [1], Ferré, Pascal [2], Dugail, Isabelle [3] Editeur Portland Press Type Article scientifique dans une revue à comité de lecture Année 2004 Langue Anglais Date 02/2004 Pagination 103-6 Volume 32 Titre de la revue Biochemical Society Transactions ISSN 0300-5127
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Cholesterol, a cell size-dependent signal that regulates glucose metabolism and gene expression in adipocytes.
Enlarged fat cells exhibit modified metabolic capacities, which could be involved in the metabolic complications of obesity at the whole body level. We show here that sterol regulatory element-binding protein 2 (SREBP-2) and its target genes are induced in the adipose tissue of several models of rodent obesity, suggesting cholesterol imbalance in enlarged adipocytes. Within a particular fat pad...
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